Exjade Drug Lawsuit SourceExjade Side Effects: Severe Skin Rash Lawsuits

Commonly asked questions about the link between severe skin rash and Exjade:

What Is Exjade?

Exjade (deferasirox) is an oral iron chelator developed to treat chronic iron overload due to multiple long-term blood transfusions, which are necessary to treat conditions such as beta-thalassemia and other chronic anemias.

As with any treatment, there are side effects associated with Exjade. These problems are more likely to occur if the dose is too high for the level of iron overload or the rate of iron loading.

You should not use Exjade if you have severe kidney or liver disease, advanced cancer, a blood cell or bone marrow disorder or low levels of platelets in your blood. And you shouldn’t use Exjade if you’re allergic to it, or if you have:

  • Severe liver or kidney disease
  • Advanced cancer
  • Bone marrow disorder
  • Low levels of platelets in your blood

Can Exjade Cause Severe Skin Rashes?

Rashes may occur during Exjade treatment, according to the U.S. Food and Drug Administration.

For rashes of mild to moderate severity, Exjade may be continued without dose adjustment, since the rash often resolves spontaneously. In severe cases, Exjade may be interrupted.

Reintroduction at a lower dose with escalation may be considered in combination with a short period of oral steroid administration.

The following skin conditions have been reported during Exjade treatment:

  • Stevens-Johnson Syndrome (SJS)
  • Toxic Epidermal Necrolysis (TEX)
  • Erythema multiforme

In severe cases, please stop taking Exjade and consult your doctor or pharmacist right away.

What is Stevens-Johnson Syndrome (SJS)?

Stevens Johnson Syndrome or Toxic Epidermal Necrolysis is a severe allergic drug reaction. According to the Stevens-Johnson Syndrome Foundation, the reaction can cause the following symptoms:

  • Painful Blistering of the skin and mucous membrane involvement
  • In many cases, it’s preceded with flu-like symptoms and a high fever
  • As it evolves, the skin literally sloughs off
  • Ocular involvement includes: severe conjunctivis, iritis, palpebral edema, conjunctival and corneal blisters and erosions, and corneal perforation

This is not a complete list of side effects and others may occur.

What is Toxic Epidermal Necrolysis (TEX)?

Also known as Lyell’s syndrome, Toxic Epidermal Necrolysis is a rare, life-threatening skin condition that can be caused by a reaction to Exjade. It may occur in all age groups.

It is characterized by blisters that meld into one another to cover a substantial portion of the body, and extensive peeling or sloughing off of skin (exfoliation and denudation). The exposed under layer of skin (dermis) is red and suggests severe scalding.

According to the Stevens-Johnson Syndrome Foundation, the reaction can cause the following symptoms:

  • Skin lesions
  • Skin blisters
  • Mucous membrane lesions
  • Mouth rash
  • Mouth blisters

This is not a complete list of side effects and others may occur.

Treatments for Toxic Epidermal Necrolysis include:

  • Hospitalization
  • Intravenous feeding
  • Medications
  • Oral steroids
  • Antihistamines

What is Erythema multiforme?

Erythema multiforme is a skin condition considered to be a hypersensitivity reaction to infections or drugs, including Exjade. It consists of a polymorphous eruption of macules, papules, and characteristic “target” lesions that are symmetrically distributed with a propensity for the distal extremities, according to the American Academy of Family Physicians.

The most important treatment is usually symptomatic. Treatments for Erythema multiforme include:

  • Oral antihistamines
  • Analgesics
  • Local skin care
  • Soothing mouthwashes (eg, oral rinsing with warm saline or a solution of diphenhydramine, xylocaine, and kaopectate)
  • Topical steroids may be considered

For more severe cases, meticulous wound care and use of Burrow or Domeboro solution dressings may be necessary, according to Medscape.

Can I File An Exjade Severe Skin Rash Lawsuit?

Our Exjade drug lawyers can help if you or someone you care about has been harmed by this medication. Lawsuits are being investigated against the device maker by both patients and their families, seeking compensation for their pain and suffering. You may be entitled to a settlement.

We do not charge any legal fees at all to pursue a claim. We will pay all the case costs and litigation expenses. Only after you receive your settlement will you be responsible for payment. If your claim is unsuccessful for any reason, you will owe nothing. We put it all in writing for you.

How Many Exjade Severe Skin Rash Lawsuits Have Been Filed?

Novartis AG recently agreed to pay $390 million to settle a lawsuit in which the U.S. government claimed the Swiss company paid kickbacks to pharmacies to boost sales of some of its prescription drugs, including Exjade.

The U.S. sued Novartis over Exjade, claiming the company had referred patients to specialty pharmacies and paid kickbacks in the form of rebates to get those pharmacies to recommend the drug to patients and to increase sales.

“We are not admitting liability, we are also not denying it,” Novartis Chief Executive Officer Joe Jimenez told Bloomberg. “We are just settling it and putting it behind us.”

The U.S. Department of Justice was seeking $3.3 billion in fines and damages.

The U.S. claimed Novartis gave pharmacies rebates to recommend Exjade to patients over generic alternatives, or to keep dispensing them, Bloomberg reported.

The government reportedly said specialty pharmacies also submitted thousands of fraud-tainted reimbursement claims to Medicare and Medicaid for the two drugs.

The settlement allows Novartis to avoid a trial that was set for Nov. 2 in Manhattan federal court.

What Are The Serious Side Effects Of Exjade?

Bleeding in the stomach or intestines reportedly occurred more often in elderly patients. If you notice any of the following unlikely but serious side effects, stop taking deferasirox and consult your doctor or pharmacist right away.

  • Severe stomach/abdominal pain
  • Black/tarry/bloody stools
  • Vomit that looks like coffee grounds
  • Severe stomach/abdominal pain
  • Loss of appetite
  • Nausea
  • Diarrhea

This is not a complete list of side effects and others may occur.

What Are The Less Serious Side Effects Of Exjade?

RxList lists some of the less serious side effects associated with the use of Exjade, these side effects include:

  • Nausea
  • Vomiting
  • Stomach/abdominal pain
  • Diarrhea
  • Dizziness
  • Anxiety
  • Tired Feeling
  • Sleep Problems
  • Rash
  • Discolored skin
  • Headache/fever
  • Cough
  • Sinus pain
  • Runny/stuffy nose  

Our Exjade Skin Rash Case Lawyers Can Help

Our dangerous drug attorneys can help if you or someone you care about was harmed by Exjade. Lawsuits have reportedly been filed against the drug manufacturer, Novartis, by both patients and their families seeking compensation for injuries caused. You may be entitled to a settlement.

We do not charge any legal fees unless you receive a settlement and we pay all of the case costs. If your claim is not successful for any reason, you do not owe us anything. We put it all in writing for you. Our lawyers will help you file your lawsuit.

Our No-Fee Promise on Exjade Skin Rash Cases

You can afford to have our great team of lawyers on your side. When you choose us, it literally costs nothing to get started. We promise you in writing:

  • No money to get started
  • We pay all case costs and expenses
  • No legal fees whatsoever unless you receive a settlement
  • Phone calls are always free.

Start Your Exjade Severe Skin Rash Cases Claim

Our Exjade skin rash case lawyers will help you file your lawsuit. To get started, you can:

  1. Submit the Free Case Review Box on this page, or
  2. Call (866) 280-3417 any time of day to tell us about your case.

We will listen to your story and answer your questions. If you have claim, we will start immediately.

WARNING: There are strict time deadlines for filing Exjade severe skin rash lawsuit claims.

View Sources

  1. Erythema Multiforme – American Academy of Family Physicians
  2. Lyell’s Syndrome – U.S. National Library of Medicine
  3. Stevens-Johnson Syndrome – Mayo Clinic