Onglyza Drug Lawsuit Source

Onglyza Complications: Heart Attacks, Heart Failure & Pancreatic Cancer

Important complications and side effect information about Onglyza (saxagliptin):

Onglyza Heart Failure, Heart Attacks & Pancreatic Cancer Complications

Onglyza (saxagliptin) is a popular medication among people who suffer from type 2 diabetes.

Unfortunately, recent studies have suggested that there may be a link to dangerous side effects associated with the use of this drug. There have been reports of increased risk of heart failure, heart attacks, pancreatic cancer, and severe joint pain in some patients who have been prescribed this medication.

The United States Food & Drug Administration has issued several safety communications that have specifically address Onglyza and the class of drugs it belongs to, known as DPP-4 inhibitors. In the latest safety communication released on April 5, 2016, the FDA warns that there may be an increased risk of heart failure associated with Onglyza.

Lawsuits are being investigated by our legal team for people who have suffered complications after using Onglyza. You may be able to recover compensation if you have been harmed. On the page below, you will find more information about Onglyza side effects and complications.

Onglyza & Heart Attacks

In April 2015, the FDA voted to require AstraZeneca to place a warning on Onglyza’s label, warning patients and doctors of a possible increased risk of heart failure.

The decision was made after reviewing data from the SAVOR study.

According to the SAVOR study, Onglyza patients were more likely to be hospitalized with heart failure than were patients in the control arm. There was a 27 percent difference in heart failure hospitalizations between the Onglyza group and the control group, according to the study. Of the study’s 16,000 subjects, 1,222 reported a major cardiovascular event.

Onglyza Complications: Heart Attack and Heart Failure Lawsuits

Onglyza has been issued a “black box warning” on its label, which suggests a link between Onglyza and heart failure.  A black box warning is reserved for the most severe side effects a medication can have.

Heart failure is not the same as a heart attack, but the complications arising from heart failure may include a heart attack.

If you or a loved one suffered from a heart attack or other serious complication as a result of taking Onglyza, you may have a legal claim.

What Are The Symptoms of a Heart Attack?

Patients taking Onglyza should contact their health care professionals right away if they develop signs and symptoms of heart failure and heart attacks such as:

Heart Failure/Heart Attack Signs & Symptoms 
Unusual shortness of breath during daily activities
Trouble breathing when lying down
Tiredness, weakness, or fatigue
Weight gain with swelling in the ankles, feet, legs, or stomach

Onglyza & Pancreatic Cancer

In March 2013, the FDA began evaluating findings from a group of researchers who discovered cancerous cellular changes, known as pancreatic duct metaplasia, in patients who took incretin mimetics such as Onglyza. Since the time of this report, several patients have come forward who have been diagnosed with pancreatic cancer while prescribed Onglyza.

Pancreatic cancer is a particularly troubling cancer because the prognosis is often poor. This type of cancer spreads rapidly from the pancreas, and it is rarely detected in its early stages. In fact, symptoms of pancreatic cancer often do not even appear until the cancer is advanced and surgical removal is no longer an option.

Onglyza Complications: Pancreatic Cancer Lawsuits

Onglyza is a medication prescribed to patients who suffer from type 2 diabetes. It works in conjunction with a healthy diet and exercise to control blood sugar levels as well as regulate insulin levels in the body. Onglyza is a member of the group of drugs known as Dipeptidyl peptidase-4 inhibitors, or DPP-4 inhibitors.

This class of drugs is relatively new, with the first of its class being introduced in 2006. DPP-4 inhibitors have been surrounded with controversy since they were introduced to the market. One of the most troubling complications believed to be associated with Onglyza and other DPP-4 inhibitors is the risk of pancreatic cancer.

Lawsuits are being investigated for patients who have been diagnosed with pancreatic cancer after being prescribed Onglyza. Pancreatic cancer is the single most deadly form of cancer, boasting a five-year survival rate of about 6%. This is due to pancreatic cancer being extremely difficult to detect in its early stages. It is not uncommon for this form of cancer to first be detected after it has already spread to other areas of the body, making it nearly impossible to eradicate.

What Are The Symptoms of Pancreatic Cancer?

Pancreatic cancer is notorious for not showing symptoms until more advanced stages. However, it is important to understand what to be aware of if you are using Onglyza or other DPP-4 inhibitors. The table below outlines some of the most common symptoms of pancreatic cancer.

Pancreatic Cancer Signs & Symptoms 
Jaundice (yellow skin)
Loss of appetite
Upper abdominal pain that shoots through the back
Unexpected weight loss
Blood clots


Onglyza & Pancreatic Cancer Lawsuits

The United States Food and Drug Administration released a safety communication on March 3, 2013, warning the public that use of DPP-4 inhibitors may cause an increased risk of heart failure and pancreatic cancer in some individuals. Lawsuits are being investigated by legal teams across the county as more adverse effects are reported by patients.

Litigation against makers of DPP-4 inhibitors would not come with a surprise, as multiple lawsuits have already been filed against other drugs of the same class, including Byetta and Januvia.

At this time, it is unclear if lawsuits against Onglyza will be filed as individual lawsuits or a class action lawsuit. However, if you believe Onglyza has contributed to a diagnosis of pancreatic cancer in your family, you may be entitled to file a lawsuit and recover compensation. It is important to contact an attorney as soon as possible so you can receive information and potentially receive a settlement.

To file an Onglyza pancreatic cancer lawsuit, the following criteria must be met:

  • Suffered from pancreatic cancer
  • Took the drug for at least one year prior to diagnosis

In general, Onglyza lawsuits are filed individually by each plaintiff and are not class actions.

Our Onglyza Lawyers Can Help

Our dangerous prescription drug lawyers can help if you or a loved one has been harmed after taking Onglyza.

Lawsuits are being investigated for serious complications that have caused pain and suffering in many patients. You may be entitled to a settlement.

We do not charge any legal fees unless we win your case, and we will pay for all case costs and litigation expenses. If your claim in not successful for any reason, you will owe us nothing. We put that all in writing for you. We’ll help you file you’re Onglyza lawsuit.

Our No-Fee Promise on Onglyza Cases

You can afford to have our great team of DPP-4 inhibitor lawyers on your side. If you choose us, it literally costs you nothing to get started. We promise you in writing:

  • No money to get started
  • We pay all case costs and expenses
  • No legal fees whatsoever unless you receive an Onglyza settlement
  • Phone calls are always free

Start Your Onglyza Lawsuit Claim

Our Onglyza lawyers will help you file your lawsuit. To get started, you can:

  1. Submit the Free Case Review Box on this page, or
  2. Call (866) 280-4722  any time of day to tell us about your case.

We will listen to your story and answer your questions. If you have claim, we will start immediately.

WARNING: There are strict time deadlines for filing Onglyza lawsuit claims.

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View Sources

  1. FDA to Examine Pancreatic Duct Metaplasia With Incretins –
  2. FAQs About Onglyza –
  3. Onglyza Oral –