SAN JOSE — The U.S. Food and Drug Administration has indicated that Onglyza and other diabetes drugs can cause severe and debilitating joint pain in drug users.

NBC News – San Jose reports that while the drugs have already been known to cause severe side-effects including Onglyza related heart failure, this is the first occurrence of joint pain being widely acknowledged as a major health complication.

In a statement issued to the public, the FDA said:

“The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines sitagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. We Have added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.”

While the FDA has noted that side-effects can be caused by other factors besides drug use, their analysis indicated that Onglyza users face a heightened risk of developing severe joint pain. However, the FDA has yet to announce a recall or need to immediately halt the use of Onglyza, rather:

“Patients should not stop taking their DPP-4 inhibitor medicine, but should contact their health care professional right away if they experience severe and persistent joint pain.”

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