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Nexium Lawsuits: Kidney Complications

Commonly asked questions about Nexium (pregabalin):

What Is Nexium?

Nexium (esomeprazole) is a medication produced and distributed by AstraZeneca. Commonly referred to as the purple pill, Nexium is used to treat symptoms of acid reflux, widely recognized as heartburn. It can also be used to prevent gastric ulcers, which are painful sores that can appear in the lining of the stomach.

Nexium was first approved by the FDA in 2001, and the pharmaceutical industry has since seen several iterations of the drug approved and subsequently marketed to the public. The purple pill was approved as an injectable medication in 2005. In 2014, Nexium 24HR was released as an over-the-counter option.

Nexium belongs to a class of drugs known as proton pump inhibitors, or PPIs. These drugs work to reduce the production of acid in the stomach that is responsible for burning the esophagus during episodes of heartburn. Typically, doctors will not recommend or prescribe PPIs to patients until they have exhausted other alternatives, such as antacids or H2 blockers.

Unfortunately, there have been several complications associated with Nexium that have caused serious harm to people. For this reason, our dangerous drug attorneys are currently investigating lawsuits for people who have been harmed by Nexium and other PPI medications.

How Does Nexium (Purple Pill) Work?

Esomeprazole, the active ingredient in Nexium, aims to reduce the amount of acid in the stomach. It does this by decreasing the secretion of acid through inhibition of special transporters in the parietal cells of the stomach. By inhibiting these transporters (commonly known as proton pumps), Nexium is able to prevent stomach acid from forming.

Normally, when food is consumed, the production of stomach acid is increased in order to fuel digestion. A valve on the end of the esophagus know as the esophageal sphincter will then seal itself, preventing stomach acid from reaching and burning the esopagus. However, in people who suffer from chronic indigestion and regularly experience heartburn, the esophageal sphincter malfunctions and does not properly close. Stomach acid is then pushed up through the esophagus, causing a painful burning sensation.

In 2014, AstraZeneca released Nexium 24HR, a 40mg delayed release form of the drug. Available over-the-counter, Nexium 24HR is specifically designed to treat those who suffer from gastroesophageal reflux disease (GERD), a condition defined by chronic episodes of acid reflux.

Nexium Information & Dosages

Nexium is available in a plethora of different dosages ranging from 2.5mg to 40mg. It is also recommended that Nexium be taken at least one hour before meals. It is important to consult your physician about proper dosages of Nexium, as it will vary depending on the severity of the condition and the age of the patient.

Nexium has consistently ranked among the top grossing drugs in the United States every year. In 2013, Nexium sold over $6.1 billion in sales, with Abilify being the only drug selling more, with $6.4 billion. In 2015, Nexium saw a decrease in sales compared to previous years, only grossing $4.7 billion. It is possible that recent studies and reports identifying dangerous side effects of PPIs may have contributed to this decline.

What Are The Side Effects Of Nexium?

Like most medications, Nexium can cause side effects in some individuals. Below is a list of common side effects known to Nexium.

DiarrheaAbdominal Pain
Dry MouthConstipation
FlatulenceDecreased Appetite


Uncommon, but possible side effects also include:


Allergic ReactionsChest Pain
Dark UrineFast Heartbeat
Persistent Sore ThroatSevere Stomach Pain
Unusual Bruising/BleedingYellowing of Eyes/Skin

Serious Side Effects of Nexium

Since PPIs were introduced to the market in 1990, several studies have been conducted regarding the safety of these medications. More recently, reports of serious and adverse long term complications have been published.

Nexium & Kidney Disease

The Journal of the American Medical Association published a study in February 2016 identifying a link between Nexium and kidney disease. Over 10,000 participants were studied from a period ranging from 1996 to 2011. According to their findings, the use of Nexium and other proton pump inhibitors was associated with a higher risk of incident chronic kidney disease (CKD).

Nexium & Acute Kidney Injury

A 2015 study conducted by Canadian Medical Association Journal indicated a possible link between proton pump inhibitors and acute kidney injury. Acute kidney injury is a condition in which the kidneys cease functioning in a short period of time.

The study was population based and observed Ontario, Canada residents 66 years of age or older who took PPIs such as Nexium between April 2002 and November 2011. Almost 300,000 PPI users were studied and compared to an equal size control group. The analysis measured hospital admissions for acute kidney injury as well as interstitial nephritis, a condition that can lead to kidney failure. The researchers concluded there was nearly a three times greater rate of acute kidney failure among the group who was using PPI medications.

Nexium & Dementia

Dementia is a category of degenerative brain diseases with a wide range of symptoms ranging from memory distortions to serious behavioral and psychological symptoms. There is currently no cure for these conditions. Approximately 36 million people are affected by different types of dementia globally. It is believed as average lifespan for humans continues to increase, so does the rate of dementia. Nearly half of all people over 85 years and older will suffer from dementia.

A prominent German study published in February 2016 associated Nexium and other PPIs with dementia. The research found that there was a 44 percent increased risk of dementia in users of PPI medication compared to those who were not taking the drug.

Has There Been Legal Action Against Nexium?

The recent medical studies and reports that have suggested dangerous side effects of Nexium and other proton pump inhibitors have prompted the FDA to release new warnings for these drugs. Lawsuits against AstraZeneca, the producers of Nexium, are being investigated for failing to produce a safe and effective medication. Families and loved ones who have suffered kidney injuries or dementia after taking PPIs may be entitled to compensation.

Prior to these new studies, Nexium has already been the subject of multiple lawsuits dating back to 2011. A 2014 class action lawsuit against AstraZeneca alleged Nexium caused an increase risk in bone fractures. This lawsuit prompted the FDA to make changes to the Nexium label, which now clearly states an increased risk of bone fractures in the hip, wrists, and spine.

AstraZeneca has faced several lawsuits over recent years, with an antitrust suit being settled for $7.9 million and a deceptive marketing suit for $20 million. An additional $24 million was paid in a separate lawsuit by Teva Pharmaceuticals for taking part in an illegal “paid-for-delay” kickback scheme in which Teva accepted payments from AstraZeneca to withhold their generic version of Nexium and potential competitior from entering the market. It is expected that lawsuits against Nexium will continue to be filed as more information becomes available about the potential kidney complications the drug may cause.

Our No Fee Promise on Nexium Cases

You can afford to have our great team of Nexium lawyers on your side. If you choose us, it literally costs you nothing to get started. We promise you in writing:

  • No money to get started
  • We pay all case costs and expenses
  • No legal fees whatsoever unless you receive a Nexium settlement
  • Phone calls are always free

Can I start a Nexium claim?

Our Nexium lawyers will help you file your lawsuit. To get started, you can:

  1. Submit the Free Case Review Box on this page, or
  2. Call (866) 280-4722 any time of day to tell us about your case.

We will listen to your story and answer your questions. If you have claim, we will start immediately.

WARNING: There are strict time deadlines for filing Nexium lawsuit claims.

Nexium Side Effects, Recall Information & Settlements

Learn more about Nexium lawsuits.

Get information about Nexium recalls.

Find a Nexium lawyer here.

Nexium News – Lawsuits, Settlements, Information

View Sources

  1. 10 Best Selling Brand Name Drugs of 2015
  2. Esomeprazole – Wikipedia
  3. Analyzing News About Proton Pump Inhibitors & Dementia – HealthNewsReview.org
  4. Top 100 Selling Drugs of 2013 – MedScape
  5. How Does Nexium Work – LiveStrong.com
  6. Nexium Uses, Dosages, Side Effects – Drugs.com