Nexium Drug Lawsuit Source

Nexium Complications: Kidney Damage

Commonly asked questions about Nexium and its link to kidney damage

Can Nexium Cause Kidney Damage?

The proton pump inhibitor Nexium has consistently ranked among the top selling drugs in the United States since it was first introduced to the market in 2001. Millions of Americans have used Nexium and other proton pump inhibitors to control symptoms of heartburn, otherwise known as acid reflux.

Unfortunately, Nexium has been a subject of controversy due to various studies suggesting serious kidney complications can be brought on by the medication.

How Do Kidneys Work?

The kidneys are a critical component of the endocrine system and are responsible for filtering blood throughout the body. Humans possess two kidneys, both located on opposite sides below the rib cage. Each organ is about the size of a human fist, and resemble the shape of a bean. The kidneys are important because by filtering blood and producing urine, they are able to keep the blood clean and stable throughout the body. It is possible to survive with only one functioning kidney, however, failure of both organs can lead to serious and fatal complications.

The kidneys contain millions of microscopic filtering units known as nephrons. Inside each nephron is an even smaller unit called the glomerulus, which acts as the actual filtering unit. The glomerulus prevents proteins and blood cells from passing through it, but allows fluid and waste products to move through to a tube inside the nephron, known as a tubule. The tubule then removes minerals and sends them back into the bloodstream. The remaining fluid, or waste at this point, is transported into the bladder. This final product is known as urine.

How Does Nexium Affect the Kidneys?

Currently, it is not known exactly how proton pump inhibitors such as Nexium affect the kidneys, but several recent medical studies have suggested links between PPI medications and kidney complications. Some studies have also concluded there was an increased risk of complications associated with an increased dosage of proton pump inhibitors.

Nexium & Chronic Kidney Disease

Chronic Kidney Disease (CKD) is a condition marked by gradual loss of kidney function. Over 26 million Americans suffer from CKD, and millions more are at risk of developing the condition. Most cases of chronic kidney disease are caused by other conditions such as diabetes and high blood pressure, however, it is believed that some medications can increase the risk of CKD also.

A study of proton pump inhibitors in The Journal of the American Medical Association published in early 2016 suggested an association between PPI medications and CKD. Two groups were studied over a ten year period consisting of self-reported PPI users. One group contained over 10,000 Americans taking part in a national study on arteriosclerosis, while the other group was part of almost 250,000 patients of a Pennsylvania health care system. Researchers determined that an increased risk of CKD was associated with PPI use in both groups.

In their report, researchers identified a 15% increased risk of chronic kidney disease in PPI users who took the medication once a day. Alarmingly, they also reported a staggering 46% increased risk of the condition in patients who took PPIs more than once per day.

Nexium & Acute Kidney Injury

Acute Kidney Injury (AKI) is a condition that results in decreased kidney function or kidney damage within only hours or days. In some cases, acute kidney injury can lead to more serious complications such as chronic kidney disease or complete kidney failure (End-Stage Kidney Disease).

The Canadian Medical Association Journal (CMAJ) pubished a study in 2015 identifying a link between proton pump inhibitors and acute kidney injury. The nine year study looked at Canadian residents 66 years of age or older who regularly took PPI drugs like Nexium. About 300,000 people were compared to an equal sized control group who did not regularly take PPI medication. The study concluded that PPI users were three times as likely to develop ACI complications than the control group.

This same study also measured the rate of interstitial nephritis that occurred in PPI users. Interstitial nephritis is a condition that causes inflammation of the kidneys and can lead to more serious kidney complications such as acute kidney injury. Although the occurrence of interstitial nephritis was much less common in the study, the results still showed a three times higher rate of the condition in users of proton pump inhibitors.

Kidney Disease in the United States

Kidney Disease affects the lives of millions of people in the United States. Kidney Disease is a blanket term that encompasses acute kidney injury, chronic kidney disease, and end-stage kidney disease (ESRD) — the total and permanent failure of the kidneys. Over 26% of the population over age 60 suffers from kidney disease; a staggering number. African American and Native American populations are at a much higher risk of kidney disease than the rest of the country.

From 1980 to 2009, the rate of kidney disease in the United States has grown over 600%. Leading unhealthy lifestyles are a major contributing factor to kidney disease. Smoking, obesity, hypertension, and high cholesterol are all believed to be risk factors for kidney disease. Diabetes, another national epidemic, is also a risk factor.

Entangled within this time period was the rise of proton pump inhibitor medication. Beginning in 1989 with the approval of omeprazole, PPI drugs such as Nexium achieved billions of dollars in sales. With more new studies being published regarding Nexium and the risk of kidney complications, some have questioned whether these drugs could also be a contributing factor to the sharp rise in kidney disease in the United States.

What Are The Severe Side Effects Associated With The Use of Nexium?

According to the American Medical Association there are several severe side effects that you should be on the lookout for when taking the prescription drug Nexium, there side effects include:

  • Acute kidney injury– is a condition that results in decreased kidney function or kidney damage within only hours or days. In some cases, acute kidney injury can lead to more serious complications such as chronic kidney disease or complete kidney failure
  • Chronic kidney disease – Is a condition marked by gradual loss of kidney function.
  • Dementia – Dementia is a category of degenerative brain diseases with a wide range of symptoms ranging from memory distortions to serious behavioral and psychological symptoms.

What Are The Less Severe Side Effects Associated With The Use Of Nexium?

Like most medications, Nexium can cause side effects in some individuals. Below is a list of common side effects known to Nexium.

  • Nausea 
  • Headache
  • Diarrhea
  • Abdominal Pain
  • Fatigue
  • Dizziness
  • Dry mouth
  • Constipation
  • Flatulance
  • Decreased appetite

What are the Criteria for Filing a Proton Pump Inhibitor Lawsuit?

Proton pump inhibitors (PPIs) were introduced in the late 1980s for the treatment of acid-related disorder of the upper gastrointestinal tract, including peptic ulcers and gastrointestinal reflux disorders, and are available both as prescription and over-the-counter drugs.

Drug Lawsuit Source is currently investigating PPI-induced Acute Interstitial Nephritis (AIN), which is a condition where the spaces between the tubules of the kidney cells become inflamed. The injury appears to be more profound in individuals older than 60.

While individuals who suffer from AIN can recover, most will suffer from some level of permanent kidney function loss. In rare cases individuals suffering from PPI-induced AIN will require kidney transplant.

Our top-rated lawyers are handling individual litigation nationwide and currently accepting new Proton Pump Inhibitor cases in all 50 states. Below is the criteria required for filing a proton pump inhibitor lawsuit:

  • Patient took one of the following PPIs by prescription or over-the-counter for at least one year:
    • Nexium
    • Prilosec
    • Dexilant
    • Prevacid
    • Protonix
    • Aciphex
    • Zegerid
  • Patient diagnosed with new onset of one of the following while taking the PPI:
    • Acute kidney/renal failure
    • Chronic kidney/renal disease
    • Acute interstitial nephritis

Both patients and their families are seeking compensation for damages. You may be entitled to a settlement if you were harmed by PPI’s.

Are the Makers of Nexium Facing Legal Action?

AstraZeneca, the manufacturer of Nexium, has already faced legal action regarding their purple pill. A class action lawsuit settled in 2014 alleging an increased risk of bone fractures caused by Nexium prompted a mandatory label change by the FDA. The following year, AstraZeneca was the center of three separate lawsuits which settled for a combined total of $51.9 million dollars. Allegations included deceptive marketing tactics, and pay-for-delay schemes with other big pharma manufacturers.

Currently, our legal team is investigating lawsuits against AstraZeneca for patients who have suffered kidney injuries after taking Nexium. There may be reason to believe the company did not take the necessary precautions in warning the public of the serious adverse side effects of their medication. If you or a loved one have been diagnosed with acute kidney injury, chronic kidney disease, or interstitial nephritis, you may be entitled to file a lawsuit and recover compensation.

Depending on your situation, you may be able to file an individual lawsuit, or join an existing class action lawsuit. Our attorneys can help you determine the best course of action. Compensation in these cases will help pay for medical expenses, lost wages, and pain and suffering damages.

Our No Fee Promise on Nexium Cases

You can afford to have our great team of Nexium kidney disease lawyers on your side. If you choose us, it literally costs you nothing to get started. We promise you in writing:

  • No money to get started
  • We pay all case expenses
  • No legal fees whatsoever unless you receive a Nexium settlement
  • Phone calls are always free

Start Your Nexium Lawsuit Claim

Our Nexium lawyers will help you file your lawsuit. To get started, you can:

  1. Submit the Free Case Review Box on this page, or
  2. Call (866) 280-3417 any time of day to tell us about your case.

We will listen to your story and answer your questions. If you have claim, we will start immediately.

WARNING: There are strict time deadlines for filing Nexium lawsuit claims.

Nexium Lawyer Review

Drug Lawsuit Source Client Review
Review Date
Prescription Drug Lawyer
Client Rating